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with antigen and co-stimulatory molecules needed for bio-mimicking the proper presentation to T cells and their following activation and proliferation. These examples collectively point out that initial cellular activation can be modulated by nanoscale floor topography alone and highlight how the multitude of strategies and topographies can differentially have an effect on cell responses. Different nanoscale topographies have additionally been explored for his or her interplay with cells . However, larger surface patterns, ranging between 10 and a hundred μm,

 

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