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time on balance, increase the number of unmethylated cytosine sites relative to those methylated, following air pollution exposure. A decrease in 5-mC could also be mediated by enhanced conversion of 5-mC to 5-hmC, with subsequent conversion to 5-fC or 5-caC followed by excision-repair (Fig.1). Lower DNAm was also found in a study of older male volunteers living in Boston, which assessed the effects of exposure to PM, black carbon, and O3 on DNAm in the blood associated with five

 

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